Virtual manufacturing technology has been applied in actual production sites with the development of virtual reality technology. However, the current virtual manufacturing technology requires experts for application of the system. Furthermore, the sense of reality is diminished as the entire simulation is driven by virtual objects. In contrast, mixed reality can visualize virtual objects and an actual work place simultaneously, and thus the sense of reality of the virtual manufacturing simulation can be improved. This paper introduces a method that applies mixed reality in the manufacturing process, and proposes a method to adapt general safety sign post in the factory instead of a black square marker for visual fiducial recognition.