While the average-case performance is important for general-purpose applications, worst-case performance is crucial for real-time systems to ensure schedulability and reliability. Recent work has shown that simple prefetching techniques such as the Next-N-Line prefetching can benefit both average-case and worst-case performance; however, the improvement on the worstcase execution time (WCET) is rather limited and inefficient. This paper presents two instruction prefetching approaches that are specially designed to enhance the worst-case performance, including the loop-based prefetching and WCET-oriented prefetching. Our experiments indicate that both instruction prefetching techniques can achieve better worst-case execution cycles than the Next-N-Line prefetching while having various impacts on the average-case performance.