Active components in Chinese quince were extracted by using high efficient microwave-assisted extraction. In accordance with central composited design, 20 runs with 3 variables and 5 levels applied for the optimization in response surface methodology system. The extracts were analyzed by spectrophotometeric methods for the total flavonoids content (TFC), total phenolic compound (TPC) and electron donating ability (EDA). The optimum conditions obtained were 44.15% ethanol concentration, 5 min extraction time and 102.1 W microwave power for maximum TFC (477.8 mg RE/100 g), TPC (2249 mg GAE/100 g) and EDA (77.47%) as predicted by overlaid contour plots.