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Betulinic and Oleanolic Acids Isolated from Forsythia suspensa VAHL Inhibit Urease Activity of Helicobacter pylori
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  • Betulinic and Oleanolic Acids Isolated from Forsythia suspensa VAHL Inhibit Urease Activity of Helicobacter pylori
  • Betulinic and Oleanolic Acids Isolated from Forsythia suspensa VAHL Inhibit Urease Activity of Helicobacter pylori
저자명
Shin. Seung-Jung,Park. Chan-El,Baek. Nam-In,Chung. In-Sik,Park. Chang-Ho
간행물명
Biotechnology and bioprocess engineering
권/호정보
2009년|14권 2호|pp.140-145 (6 pages)
발행정보
한국생물공학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Sixteen medicinal herbs were selected from a database on traditional herbal materials as well as literature on Korean plant resources. Then ethanol (70%, v/v) extracts of these herbs were tested for inhibition of the urease activity of Helicobacter pylori. The urease activity of H. pylori was strongly (82%) inhibited by extract of Forsythia suspensa $V_{AHL}$. Active compounds in extract of Forsythia suspensa $V_{AHL}$ were first separated by batch mode solvent extraction, followed by purification by silica gel and octadecyl silica gel column chromatography using solvents of different polarity. According to NMR analysis of the last chromatographic fraction, we identified the presence of betulinic acid and oleanolic acid, which are known to have anti-inflammatory, anti-cancer, and anti-HIV viral activities.