5,7-Dimethoxyflavone, a major compound from Kaempferia parviflora, was used as a starting material for structural modification. Seven flavonoid derivatives have been synthesized from this flavone. Two new oxime derivatives 4 and 6 exhibited cytotoxicity against HepG2 cell line with $IC_{50}$ values of 36.38 and $25.34;{mu}g/mL$, respectively, and against T47D cell line with $IC_{50}$ values of 41.66 and $22.94;{mu}g/mL$, respectively. Compound 7 showed cytotoxicity against HepG2 and T47D cell lines with $IC_{50}$ values of 21.36 and $25.00;{mu}g/mL$, respectively. Compounds 6 and 7 showed cytotoxicity nearly equal to the tamoxifen standard. In addition, oxime 6 exhibited antifungal activity against Candida albicans with an $IC_{50}$ value of $48.98;{mu}g/mL$.