It has been well known that the infiltration of rainfall causes major surfacial slope failures in Korea. However, the hydrological and mechanical behaviors in unsaturated slopes are somewhat complex. When an analysis on unsaturated slope problems is performed, soil-water characteristics curves (SWCC) are considered as major parameters to apply. Since the weathered soil slopes are layered and stressed by overburden pressures, the response of SWCCs should account for its overburden pressure. To deal with this situation, in this study, laboratory testings were conducted to evaluate the SWCC under various overburden stress. In addition, the unsaturated shear strength was estimated using SWCC. Then the performance of unsaturated weathered soil slopes was evaluated under various conditions after applying the effect of overburden pressure on SWCCs. The results demonstrated that the effect of overburden pressure on SWCC could be substantial and the proper application to analysis is very important to enhance the prediction of slope stability.