In a two-inertia motor system with flexible shaft, a torsional vibration is often generated as a quick speed response is required. This vibration makes it difficult to achieve a quick response of speed and disturbance rejection. The objective of this paper is to provide a systematic analysis and design of the three kinds of speed controllers such as I-P, I-PD, and state feedback control by using the weighted ITAE performance index. Some simulation and experiment results verify the effectiveness of the proposed design.