- 삼정환(三精丸)이 고지방(高脂肪) 식이(食餌) 흰 쥐의 비만에 미치는 영향
- ㆍ 저자명
- 김지형,김근우,구병수,Kim. Ji-Hyung,Kim. Geun-Woo,Koo. Byung-Soo
- ㆍ 간행물명
- 동의신경정신과학회지
- ㆍ 권/호정보
- 2009년|20권 2호|pp.47-60 (14 pages)
- ㆍ 발행정보
- 대한한방신경정신과학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Objectives : This study was performed to show the effects of Samjung-hwan ($S{={a}}nj{={i}}ngw{'{a}}n$) extract on obesity and lipid metabolism of rats fed high fat diet. Methods : Crushed Samjung-hwan($S{={a}}nj{={i}}ngw{'{a}}n$) 245 g was extracted with methyl alcohol. The extract was evaporated under reduced pressure to give 21.8 g. 20 rats were divided into normal, control, and two test groups. For 6 weeks, The normal group rats were supplied with a normal diet. The control group rats were supplied with a high fat diet. The test group 1 rats were supplied with a high fat diet and Samjung-hwan($S{={a}}nj{={i}}ngw{'{a}}n$) extract 250 rug/kg and the test group 2 rats were supplied witha high fat diet and Samjunghwan($S{={a}}nj{={i}}ngw{'{a}}n$) extract 500 mg/kg. Results : 1) The control group rats showed significantly increased weight of peritoneal fat than the nornal group rats. The test group 1 rats did not show significant difference compare to the control group rats, and the test group 2 rats showed significantly decreased weight of peritoneal fat than the control group rats. 2) The control group rats showed significantly increased triglyceride than the nornal group rats. The test group 1 rats showed significantly decreased triglyceride than the control group rats, and the test group 2 rats showed significantly decreased triglyceride than the control group rats. 3) The control group rats showed significantly increased LDL-cholesterol than the nornal group rats. The test group 1 rats showed significantly decreased LDL-cholesterol than the control group rats, and the test group 2 rats did not show significant difference compare to the control group rats. Conclusions : These results suggest that effectiveness of Samjung-hwan($S{={a}}nj{={i}}ngw{'{a}}n$) extract to control the obesity and abnormal lipid metabolism caused by a high fat diet.