As R&D environment was changed, the research through Cyberinfrastructure emerged as a new paradigm. Advanced countries such as U.S. and U.K. invested heavily in the system for advancing R&D by building national Cyberinfrastructure. It is required to analyze how to build and utilize Cyberinfrastructure in science and technology. This paper aims to investigate and analyze the utilization status and demand of Cyberinfrastructure and to propose directions for operating it in Korea. This study is expected to be a principle foundation for decision making about developing it.