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Tandem Repeats (CCTTT)n in the Promoter of iNOS Gene in Korean Genome
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  • Tandem Repeats (CCTTT)n in the Promoter of iNOS Gene in Korean Genome
  • Tandem Repeats (CCTTT)n in the Promoter of iNOS Gene in Korean Genome
저자명
유민,Yoo. Min
간행물명
Journal of experimental & biomedical sciences
권/호정보
2009년|15권 2호|pp.167-170 (4 pages)
발행정보
대한의생명과학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Nitric oxide is an important factor to regulate the biochemical reactions in the body such as expansion of blood vessel, neural conduction and antimicrobial activity. There are two forms of nitric oxide synthase and iNOS has attracted most attention because it is involved in the development of diabetes and cardiac disease condition. There are several regulatory sequences in the promoter region of iNOS gene. One of them is (CCTTT)n. It has been reported that the number of tandem repeat of (CCTTT)n varies from population to population. So, we analyzed (CCTTT)n polymorphism in Korean genome for the purpose of comparison. According to our present study Koreans are different from other Asians reported previously because $(CCTTT)_{10}$ is the highest incidence as opposed to $(CCTTT)_{12}$ for other countries. This study should facilitate the understanding of the expression of iNOS gene in different population.