In this paper, we introduce the architecture of Genetic Algorithm(GA) based Feed-forward Polynomial Neural Networks(PNNs) and discuss a comprehensive design methodology. A conventional PNN consists of Polynomial Neurons, or nodes, located in several layers through a network growth process. In order to generate structurally optimized PNNs, a GA-based design procedure for each layer of the PNN leads to the selection of preferred nodes(PNs) with optimal parameters available within the PNN. To evaluate the performance of the GA-based PNN, experiments are done on a model by applying Medical Imaging System(MIS) data to a multi-variable software process. A comparative analysis shows that the proposed GA-based PNN is modeled with higher accuracy and more superb predictive capability than previously presented intelligent models.