Membrane structures are quite sensitive to wind and therefore the fluid-solid interaction can not be neglected in dynamic analysis. A boundary element method (BEM) for 3D simulation of wind-structure interaction in tensile membrane structures is presented in this paper. The flow is treated as incompressible and potential. The flow field is solved with boundary element method codes and structural simulation is performed by finite element method software ANSYS. The nonlinear equations system is solved iteratively, with segregated treatment of the fluid and structure equations. Furthermore this method has been demonstrated to be effective by typical examples. Besides, the influence of several parameters on the wind-structure interaction, such as rise-span ratio, prestress and the wind velocity are investigated according to this method. The results provide experience in wind resistant researches and engineering.