In order to perform a step-by-step force-displacement response analysis or dynamic time-history analysis of large buildings with masonry infilled R/C frames, a continuous force-deformation model based on an equivalent strut approach is proposed for masonry infill panels containing openings. The model, which is applicable for degrading elements, can be implemented to replicate a wide range of monotonic force-displacement behaviour, resulting from different design and geometry, by varying the control parameters of the model. The control parameters of the proposed continuous model are determined using experimental data. The experimental program includes fifteen 1/3-scale, single-story, single-bay reinforced concrete frame specimens subjected to lateral cyclic loading. The parameters investigated include the shape, the size, the location of the opening and the infill compressive strength. The actual properties of the infill and henceforth the characteristics needed for the diagonal strut model are based on the assessment of its lateral resistance by the subtraction of the response of the bare frame from the response of the infilled frame.