The present contribution addresses the parallelization of advanced simulation methods for structural reliability analysis, which have recently been developed for large-scale structures with a high number of uncertain parameters. In particular, the Line Sampling method and the Subset Simulation method are considered. The proposed parallel algorithms exploit the parallelism associated with the possibility to simultaneously perform independent FE analyses. For the Line Sampling method a parallelization scheme is proposed both for the actual sampling process, and for the statistical gradient estimation method used to identify the so-called important direction of the Line Sampling scheme. Two parallelization strategies are investigated for the Subset Simulation method: the first one consists in the embarrassingly parallel advancement of distinct Markov chains; in this case the speedup is bounded by the number of chains advanced simultaneously. The second parallel Subset Simulation algorithm utilizes the concept of speculative computing. Speedup measurements in context with the FE model of a multistory building (24,000 DOFs) show the reduction of the wall-clock time to a very viable amount (<10 minutes for Line Sampling and ${approx}$ 1 hour for Subset Simulation). The measurements, conducted on clusters of multi-core nodes, also indicate a strong sensitivity of the parallel performance to the load level of the nodes, in terms of the number of simultaneously used cores. This performance degradation is related to memory bottlenecks during the modal analysis required during each FE analysis.