The characteristic response of a structure to blast load may be divided into two distinctive phases, namely the direct blast response during which the shock wave effect and localized damage take place, and the post-blast phase whereby progressive collapse may occur. A reliable post-blast analysis depends on a sound understanding of the direct blast effect. Because of the complex loading environment and the stress wave effects, the analysis on the direct effect often necessitates a high fidelity numerical model with coupled fluid (air) and solid subdomains. In such a modelling framework, an appropriate representation of the blast load and the high nonlinearity of the material response is a key to a reliable outcome. This paper presents a series of calibration study on these two important modelling considerations in a coupled Eulerian-Lagrangian framework using a hydrocode. The calibration of the simulated blast load is carried out for both free air and internal explosions. The simulation of the extreme dynamic response of concrete components is achieved using an advanced concrete damage model in conjunction with an element erosion scheme. Validation simulations are conducted for two representative scenarios; one involves a concrete slab under internal blast, and the other with a RC column under air blast, with a particular focus on the simulation sensitivity to the mesh size and the erosion criterion.