When a roof frame is subjected to the airblast loading, the conventional way to analyze the damage of the frame or design the frame is to use single degree of freedom (SDOF) model. Although a roof frame consists of beams and girders, a typical SDOF analysis can be conducted only separately for each component. Thus, the rigid body motion of beams by deflections of supporting girders can not be easily considered. Neglecting the beam-girder interaction in the SDOF analysis may cause serious inaccuracies in the response values in both Pressure-Impulse curve (P-I) and Charge Weight-Standoff Diagrams (CWSD). In this paper, an inelastic two degrees of freedom (TDOF) model is developed, based on force equilibrium equations, to consider beam-girder interaction, and to assess if the modified SDOF analysis can be a reasonable design approach.