This paper presents a computational study for the structural response of blast loaded metallic sandwich panels, with the emphasis placed on their failure behaviours. The fully-clamped panels are square, and the honeycomb core and skins are made of the same aluminium alloy. A material model considering strain and strain rate hardening effects is used and the blast load is idealised as either a uniform or localised pressure over a short duration. The deformation/failure procedure and modes of the sandwich panels are identified and analysed. In the uniform loading condition, the effect of core density and face-sheets thicknesses is analysed. Likewise, the influence of pulse shape on the failure modes is investigated by deriving a pressure-impulse (P-I) diagram. For localised loading, a comparative study is carried out to assess the blast resistant behaviours of three types of structures: sandwich panel with honeycomb core, two face-sheets with air core and monolithic plate, in terms of their permanent deflections and damage degrees. The finding of this research provides a valuable insight into the engineering design of sandwich constructions against air blast loads.