In the literature the problem of the topology optimization of the structure is usually solved for one, clearly described from the mechanical point of view material. Generally the topology optimization answers the question of the distribution of this mentioned above material within the design domain. Finally, material-voids distribution it is obtained. In this paper, for the structure mainly strengthened or sometimes weakened by the inclusions, the variation approach of the topology optimization problem is formulated. This multi material approach may be useful for the design process of various mechanical or civil engineering structures which need to be more "refined" and more "optimal" than they can be using previous topology optimization procedures of optimization one material structures.