The purpose of this study was to examine the characteristics of prosody of utterance of ambiguous sentences in patients with neurogenic communication disorders. Ambiguous words on which prosody may have an impact were used to investigate this matter. The characteristics of tone duration, pitch and intensity were analyzed to examine the characteristics of prosody in patients with lesions in the left or right hemisphere and normal controls. The whole process was recorded using a Praat 4.3.14 and for statistical analyses, two-way Anova and multiple comparative analyses were carried out using SPSS10.0 for Windows. The conclusions of this study are as follows: The length of vowel in homograph in Korean was different depending on the meaning and the duration of vowel was the longest in patients with lesions in the left hemisphere. There was agreed that they had problem of timing of prosody(Danly & Shapiro, 1982). On the other hand, there found that patients with lesions in the right hemisphere had deficiency of changeability in pitch. Among various acoustic parameters, this study focused on the duration which are closely related to suprasegmental characteristics of prosody. More acoustic parameters should be taken into account in future studies.