This study analyze the effect of machine tools, cooling lubrication environments and cutting conditions on surface roughness and cutting force, and propose the combination of cutting conditions which minimizes the effect of machine tool variables on the dispersion of cutting force and surface roughness by treating the changes in machine tool itself and the installation environments as a noise factors. To do so, the Taguchi method is used to establish an experiment plan, and flat end milling is carried out to measure cutting force and surface roughness. The research results show that in the case of cutting force, the effect of cutting conditions is dominant, and changes in machine tools and cooling lubrication environments barely have effect on cutting force. However, in the case of surface roughness, all of the cutting conditions, machine tool and cooling lubrication environment variables have impact. In order to select a combination of cutting conditions insensible to changes in machine tools, considerations for feed per revolution and axial depth of cut turn out most important in the aspect of cutting force, and considerations for feed per revolution is most important in the surface roughness.