Based on the boundary element method, the motion responses and transmission coefficients of a moored floating breakwater were investigated in oblique waves. To satisfy the outgoing radiation condition in the far field, the fluid domain was divided into inner and outer regions. The complete solution could be obtained by applying the matching conditions between the eigenfunction-based outer solution and BEM-based inner solution. Using the developed predictive tools, the wave exciting forces, added mass, damping coefficients, motion responses, and transmission coefficients were assessed for various combinations of breakwater configuration, wave heading, mooring cables properties, and wave characteristics. It was found that the transmission coefficient for a moored floating breakwater was closely dependent on the motion responses, which were greatly amplified at the resonant frequencies.