The load distribution and deflection of offshore piles are investigated by lateral load-transfer curve method (p-y curve). Special attention is given to the soil-pile interaction and soil resistance of 3D wedge failure mode. A framework for determining a hyperbolic p-y curve is proposed based on theoretical analysis and experimental load test results. The methods for determining appropriate material parameters needed for constructing the proposed p-y curves are presented in this paper. Through comparisons with field case studies, it was found that the proposed method in the present study estimates reasonably the load transfer behavior of pile, and thus, the computed pile responses, such as bending moment and lateral displacement, agree well with the actual measured responses.