The purpose of this study was to examine the moderating effect of self esteem on the link between social support(e.g. from family, friends and significant others) and career decision-making level of youth in residential care. Data for this study were collected from 14 nationwide institutions between June 10th to June 20th, 2008. Selfreporting surveys were employed to gather information from 412 sources within these institutions. Collected data were analyzed by SPSS program(12.0). The results were as follows: Stepwise multiple regression showed that self-esteem could be used to predict career decision-making level($eta$ = -.262, p < .001). Furthermore, self-esteem had a moderating effect on the relationship between social support and career decision-making level($eta$ = -.749, p < .001). Specifically, self-esteem and the scale of social support from family, friedns or significant others had a moderating effect on career decision-making level($eta$ = - .118, p < .001). The implication of these findings on career decision-making intervention of youth in residential care and future research priorities are discussed