Macroglossia is a tongue pathology of multiple etiology as systemic disease like cerebral palsy and Down syndrome etc. It can cause abnormal oral conditions including anterior open bite or dyspnea by changing occlusion and oral habits. So many handicapped children who have macroglossia need to get surgery of large tongue to improve esthetics, function, and treatment stability. The purpose of this report is to evaluate 2 patients, one has cerebral palsy and the other lymphangioma, who have experience of glossectomy with review of literature.