PVA/collagen blend fibers were produced by air-gap spinning method, and were successfully spun to blend fiber. Maximum collagen content to produce the fiber was 30%, above which the fiber was found to be broken in the drawing process. Thermal and mechanical properties of the fibers were investigated by changing blend ratios of the PVA to collagen. Melting point of PVA was decreased with the increase of the amount of collagen. The strength and the elongation of the fiber were also decreased due to the inhomogeneous structure of the blend fiber. Hot water resistance was endowed by the heat treatment after drawing process, and when the fiber was treated at $230^{circ}C$ for 10 minutes, it was neither swelled nor broken in boiling water.