The radiation of sound from a rectangular plate with a guided edge condition is investigated. By taking this particular boundary condition into account, simple analytical forms of the average radiation efficiency and radiation power based on the modal approach can be found, where the cross-modal terms can average out for all possible point excitation locations. Design variables of the plate such as thickness, aspect ratio, and damping that are closely related to the sound radiation are mainly discussed. The radiation power of the guided plate is found to be governed by the piston mode as well as the critical frequency. While both the radiation efficiency and the radiation power seem to be influenced by thickness and a large aspect ratio, damping loss factor seems less important to the radiation power. It is also shown that no clear corner and edge mode regions may be found for the guided case, unlike the pinned.