PID control is widely used to control stable processes, however, PID control for unstable processes is less common. In this paper, systematic tuning methods are derived to tune the PID controller for unstable FOPTD(Forst Order Plus Time Delay) processes. The proposed PID controllers for set-point tracking and disturbance rejection problem are tuned based on minimizing the performance indexes (IAE, ISE, ITAE) using a real-coded genetic algorithm. Simulation example is given to illustrate the set-point tracking and disturbance rejection performance of the proposed method.