This paper presents a application of new algorithm for feeder reconfiguration problem in distribution systems. Harmony Search (HS) algorithm, which is motivated from the musical performance, is used to reconfigure distribution systems so that active power losses are globally minimized with turning on/off the sectionalizing and the tie-line switches. In optimization processing, the HS algorithm has searching ability for the global optimal solution, simple coding of the iteration procedure, and fast convergence to get the solution. The HS algorithm is tested on 15 buses and 69 buses distribution systems, and the results prove its effectiveness to determine appropriate switching options without the occurrence of any misdetermination in switching and get the minimum power loss.