${eta}2$-Microglobulin (${eta}2m$) is known to be a major factor for dialysis-related amyloidosis. We have studied ${eta}2m$ removal through an aggregation process, which was initiated by a ligand that could catch the ${eta}2m$ monomer and promote its aggregation into fibril. As a ligand, we have prepared ${eta}2m$ fibril fragments and used them as a seed. The seed was coupled to PEGylated-PS beads to remove the monomeric ${eta}2m$ from solution. The ${eta}2m$ seed-conjugated resin effectively adsorbed the ${eta}2m$ monomers with a capacity of 3.6 mg/ml via promoting their aggregation into fibrils on the resin at pH 7.4.