Recently, the number of industrial structures that must be demolished due to structural deterioration and unsatisfactory functional conditions has been increased. To minimize environmental hazardous factors created during the process of demolition, the explosive demolition method has been applied increasingly. This execution case was intended to describe an application of the explosive demolition method to the demolition of a Crusher & Screen structure, which was a large-section reinforced concrete special structure. It was deemed necessary due to its structural deterioration and unsatisfactory functional condition. Various pre-weakening processes and blasting patterns were applied to the large-section reinforced concrete members, and to reduce blasting vibration and impact vibration, time intervals were established for blasting in the same column and for blasting between blasting blocks. By applying the explosive demolition method to the demolition of a large-section reinforced concrete special structure, the explosive demolition was completed safely and efficiently, without causing any damage to surrounding facilities.