Tumor necrosis factor (TNF)-${alpha}$ is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-${alpha}$ have been implicated in both the induction of atherogenic adipokines, such as plasminogen activator inhibitor (PAI)-1, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of trans-stilbene, piceatannol, rhaponticin, and piceid on the TNF-${alpha}$-induced atherogenic changes of adipokines in 3T3-L1 cells. Exposure to TNF-${alpha}$ for 24 hr increased PAI-1 secretion and decreased adiponectin secretion. Among stilbenoids, piceatannol significantly inhibited the increased secretion of PAI-1 induced by TNF-${alpha}$. Adiponectin secretion decreased by TNF-${alpha}$ was recovered after trans-stilbene and rhaponticin treatments. Our results showed that stilbenoids exerted different effects on TNF-${alpha}$-induced changes in adipokines secretion in 3T3-L1 adipocytes according to their structural characteristics.