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Ingestion of Korean Red Ginseng after Noise Exposure Can Potentiate Rapid Recovery of Hearing in Mice
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  • Ingestion of Korean Red Ginseng after Noise Exposure Can Potentiate Rapid Recovery of Hearing in Mice
  • Ingestion of Korean Red Ginseng after Noise Exposure Can Potentiate Rapid Recovery of Hearing in Mice
저자명
Kang. Woo-Seok,Chung. Jong-Woo
간행물명
Journal of ginseng research
권/호정보
2010년|34권 4호|pp.336-341 (6 pages)
발행정보
고려인삼학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

One mechanism of inner ear damage by noise-induced hearing loss (NIHL) is the production of reactive oxygen species (ROS). Because Korean red ginseng (KRG) has an anti-ROS effect in various tissues, KRG may have a role in preventing NIHL. A window period exists in which ROS formations continue after noise exposure, and further damage can be prevented by antioxidants. In this study, we aimed to investigate the effects of KRG after exposure to noise. KRG (200 mg/kg) was fed to mice for 3 days after noise exposure. The change in hearing level was analyzed by measuring the auditory brainstem response. To induce a temporary threshold shift (TTS) of hearing, mice were exposed to 110 dB white noise for 3 hours. Fast recovery of hearing was observed in mice fed KRG 1 hour and 1 day after noise exposure for 3 days. The expression of 8-oxoguanine was not observed in the inner ears of mice fed KRG 1 hour after noise exposure, but was evident in the stria vascularis of mice in the control group (noise exposure only). From this study, we conclude that KRG acted as an effective inhibitor of NIHL in TTS cases.