Breast cancer is the most prevalent woman cancer, and its prevalence rate is increasing rapidly. It is necessary to develop the breast-dedicated positron emission tomography (PET) or positron emission mammography (PEM) systems with high resolution and sensitivity to improve the accuracy of diagnosis of breast cancer. Therefore, it is necessary to develop the high-end PET system technologies, such as the measurement of depth-of-interaction (DOI) and fully digitalized data acquisition, to establish high performance breast imaging systems. In this paper, recent technical advances in breast-dedicated PET imaging systems will be reviewed.