In this study we propose a new texture feature extraction method based on an estimation of the brightness and structural uniformity of CT images representing the important characteristics for emphysema recognition. The Center-Symmetric Local Binary Pattern (CS-LBP) is first used to combine gray level in order to describe the brightness uniformity characteristics of the CT image. Then the gradient orientation difference is proposed to generate another CS-LBP code combining with gray level to represent the structural uniformity characteristics of the CT image. The usage of the gray level, CS-LBP and gradient orientation differences enables the proposed method to extract rich and distinctive information from the CT images in multiple directions. Experimental results showed that the performance of the proposed method is more stable with respect to sensitivity and specificity when compared with the SGLDM, GLRLM and GLDM. The proposed method outperformed these three conventional methods (SGLDM, GLRLM, and GLDM) 7.85[%], 22.87[%], and 16.67[%] respectively, according to the diagnosis of average accuracy, demonstrated by the Receiver Operating Characteristic (ROC) curves.