In the region of the intermediate open cluster M35 (NGC 2168), the time-series of V CCD images was taken for 12 nights from December 18, 2007 to September 25, 2010. From this observation, we detected 22 variable stars including 15 new ones. They are 6 $delta$ Scuti, a Cepheid, an RR Lyrae, 9 eclipsing binaries and 5 semi-long periodic and/or slow irregular type variable stars. For the V photometry of the $delta$2 Scuti stars, the multi-frequency analysis was performed using the Discrete Fourier Transform and the linear least-square fitting.