We present the minimum weight optimum design of cross sectional for frame structures subject to natural frequency. The optimum design in this paper employ discrete and continuous design variables and Genetic Algorithms. In this paper, Genetic Algorithms is used in optimization process, and be used the method of Elitism and penalty parameters in order to improved fitness in the reproduction process. For 1-Bay 2-Story frame structure, in examples, continuous and discrete design variables are used, and W-section (No.1~No.64), from AISC, discrete data are used in discrete optimization. In this case, Exhaustive search are used for finding global optimum. Continuous variables are used for 1-Bay 7-Story frame structure. Two typical frame structure optimization examples are employed to demonstrate the availability of Genetic Algorithms for solving minimum weight optimum of frame structures with fundamental and multi frequency.