This paper presents a novel fourth harmonic mixer with new structure. The traditional 3-ports fourth harmonic mixer and the novel fourth harmonic mixer are designed by ADS, HFSS and CST simulator. The mixers have been fabricated and tested. The size of the traditional 3-ports fourth harmonic mixer is $12{ imes}15$ mm, and the best conversion loss is 18.7 dB according to the measurement. Since the traditional 3-port mixer size is too large to be ranked, we design a novel fourth harmonic mixer for imaging system. The width of the mixing module in the novel fourth harmonic mixer is only 3.65 mm, and this size is fully capable to meet the mixer unit space which is not greater than 5 mm. The simulation result shows that the mixer has good performance, and the experiment result shows that the best conversion loss of the novel fourth harmonic mixer is 16.3 dB at RF signal of 91.3 GHz.