CQUEAN (Camera fo QUasars in EArly uNiverse) is a newly developed camera by CEOU for the 2.1m telescope at the McDonald Observatory, Texas, USA. We report the early science results from the commissioning run of CQUEAN which include the observations of the gamma-ray burst (GRB) afterglows and quasars at z ~ 5.5. Although the data were originally taken to test the instrument performance, the results are already very encouraging. We uncovered GRB afterglows at z = 0.8 - 1.4, with our data being used for the international collaboration research to understand the nature of GRBs. The unique filter sets we employed are providing the data which are effective for selecting quasars at z ~ 5.5. The special aspects of CQUEAN - high sensitivity at 0.8-1.1 ${mu}m$ and fast readouts - will allow us to produce many interesting through surveys of high redshift quasars and fast follow-up of transient objects such as GRBs and exoplanets in future.