CQUEAN (Camera for Quasars in EArly uNiverse) is an optical CCD camera system which has its own auto-guiding system. Guiding system consists of a 1k*1k CCD camera, FLI PL1001E, a flat mirror to feed the image of an off-axis field to the camera and baffle. The whole system lies on a moving arm which rotates 90 degree effectively to enlarge the field of view. A motor, IMS MDRIVE 34, and a differential decelerator, APEX AD140-050, are used for the moving mechanism. Auto-guiding is controlled by Agdr program. We had a first light from Aug. 10 to Aug 17, 2010 at McDonald Observatory, USA. In this presentation, we describe about the auto-guiding system for CQUEAN and its performance on the 2.1m telescope.