An analytical method for robust design of the multi-loop proportional-integral (PI) controller is proposed for various types of multi-delay processes. On the basis of the direct synthesis and generalized IMC-PID approach, the analytical tuning rules of the multi-loop PI controller are firstly derived for achieving the desired closed-loop response, and the structured singular value synthesis is then utilized for the tradeoffs between the robust stability and performance by adjusting only one design parameter (i.e., the closed-loop time constant). To verify the superiority of the proposed method, the simulation studies have been conducted on a wide variety of multivariable processes. The multi-loop PI controller designed by the proposed method shows a fast, well-balanced and robust response with the minimum integral absolute error (IAE) in compared with other renowned methods.