The purpose of this study is to examine moderating effect of social relationship on the relationship between academic stress and psychological health among of adolescents. This data used in this study used data was derived from the wave 2-4(2004-2006) of Korean Youth Panel Study (KYPS). The results show that social relationship(parent-child relationship and peer relationship) had a moderating effect on academic stress and psychological health of adolescents. In short, it was verified that in the case of good social relationship, academic stress could actually buffer the effect of psychological health. However, it terms of parent-child relationship, it was not confirmed to have a moderating effect on academic stress and psychological health in the 11th grade. The results from above suggest that schools and related facilities adolescent should consider the program to reinforce social relationship and the timing of the intervention.