The goal of this paper is to develope the control program based on model which can be applied to 1000MW class coal fired thermal power plant. 1000MW class power plant has the higher efficiency and lower cost because the steam conditions of the ultra super-critical process are higher than them of the previous power plants in temperature and pressure. The program includes the state variable controls which have the desired characteristics for the higher temperature and pressure. The program had been developed successfully using advanced process control. The simulation results using the new control program showed the better performance and safer control than them of the previous control program and we could verify the application possibility of the new program for the actual power plant through the load test, comparison, analysis and tuning.