With growing of wind turbine industry, offshore wind energy is getting more attention in recent years. Among all the components of offshore wind turbines, the foundation of the offshore wind turbine plays a key role in stability of whole system. In this work, the 5 MW NREL reference wind turbine with rated speed of 11.4 m/s is used for load calculation. Wind and wave loads are calculated using GH-Bladed (Garard Hassan) and FAST (NREL). Additionally, FE simulation is carried out to investigate the wave effect on the support structure. Meanwhile, this work is to simulate systemic and optimized load cases for the foundation analysis of wind turbine system.