Simultaneous production of mevinolins (natural statins) and ubiquinones (coenzyme Qs; $CoQ_9$ and $CoQ_{10}$) were identified and determined in solid substrates fermented (SSF) with Monascus pilosus K-1140. The highest co-production of mevinolins ($2.31{pm}0.11$ mg/g) and ubiquinones ($0.24{pm}0.02$ mg/g) was obtained in a mixed grains substrate (rice:sorghum:barley:buckwheat:soybean; 1:1:1:1:1; w/w/w/w/w). The optimal conditions for mixed grains in the SSF were initial moisture content of 50% and initial substrate pH of 6. The total production of CoQs was increased by 32% with the addition of red paprika. Mevinolinic acid (hypocholesterolemic agent) was the main component contributing 81.3 to 91.5% of total mevinolins in the fermented substrates. The results indicate that mixed grain fermented with M. pilosus may be used as a new nutraceuticals with anti-atherosclerotic function without statin-induced $CoQ_{10}$ deficiency.