개에서 복강수술 후 유착방지에 대한 sodium carboxymethylcellulose (SCMC), oxidized regenerated cellulose (ORC), vitamin E의 병용효과를 알아보고자 본 실험을 수행하였다. 실험견은 대조군, SCMC 처치군, ORC 처치군, SCMC와 vitamin E 처치군, ORC와 vitamin E 처치군의 5개군으로 분류하고 각 군에 5두씩 배치하였다. 정중개복 후 회장 장막에 6 cm 간격으로 5곳에 찰과상을 입혀 유착을 유발했다. 유착장소는 전군에서 장막-장간막(37.6%), 장막-장막(24%), 장막-대망막(8.8%), 장막-복막(3.2%) 순으로 발생하였다. 유착발생빈도는 SCMC와 vitamin E 처치군이 56%로 대조군 92%, SCMC 처치군 84%, ORC 처치군 64%, ORC와 vitamin E 처치군 68%에 비해 낮았다. 유착형성 점수는 SCMC와 vitamin E 처치군에서 다른 처치군에 비해 유의적인 감소를 나타내었다(p < 0.01). 따라서, 복강수술 후 유착방지에 있어 SCMC와 vitamin E의 병용이 개에서 효과적이라고 생각된다.
This study was performed to compare the efficacy of the sodium carboxymethylcellulose (SCMC), oxidized regenerated cellulose (ORC), and their combination with vitamin E for the prevention of postoperative adhesions in the dog. Twenty five dogs were randomly divided into five groups ; non-treated group (Control Group), SCMC-treated group (SCMC Group), ORC-treated group (ORC Group), vitamin E and SCMC-treated group (SCMC + E Group), and vitamin E and ORC-treated group (ORC + E group). After laparotomy, 5 abrasions were made to induce intraperitoneal adhesions on the surface of the ileal serosa. The adhesions were occurred in serosa to mesentary (37.6%), serosa to serosa (24%), serosa to omentum (8.8%) and serosa to parietal peritoneum (3.2%). The incidences of adhesions were 92%, 84%, 64%, 56% and 68% in Control, SCMC, ORC, SCMC+E and ORC + E Group, respectively. The adhesion scores in SCMC+E Group were significantly lower than those in the other groups (p < 0.01). In conclusion, this study showed that oral supplements of vitamin E and intraperitoneal administration of 2% SCMC solution were effective on reducing intraperitoneal adhesions in the dog.
