This study examined the effects of self-differentiation on family-life satisfaction and job satisfaction, and investigated the mediating effects of conflict-managing behavior. The participants in the present study were 196 married employees. LISREL was employed to test this hypothetical structural model. The results of this empirical study demonstrated that self-differentiation had positive effects on both family-life satisfaction and job satisfaction, which was mediated by the conflict-managing behavior but did not have a direct effect on either family-life satisfaction or job satisfaction. This study verified that conflict-managing behavior had mediating effects on the relationships among self-differentiation, family-life satisfaction, and job satisfaction. The results indicated that the higher the level of self-differentiation was, the more effective conflict-managing behavior was. And the more effective conflict-managing behavior was, the higher the levels of family-life satisfaction and job satisfaction were.