P-PIE program is developed for evaluating failure probability of pipes in nuclear power plants based on the existing PRAISE program. In the program, crack growth due to fatigue loading and stress corrosion can be considered and the probability of fracture or leakage of pipes can be calculated. Crack growth simulation is performed based on stress intensity factor and a damage parameter and failure of a pipe is determined based on J integral or net section yielding. Using the developed program the failure probabilities of tubes in a domestic nuclear power is obtained and discussed.