Purpose: This study was conducted to compare depression and quality of life between the Tae Yin In and So Yin In groups of the Sasangin constitution in Korean elderly women. Methods: A total of 203 (Tae Yin In=103, So Yin In=100) women aged over 65 yr, who were living in Seoul or Gyung-gi province, participated in the study. Data were analyzed by descriptive statistics, $X^2$-test, independent t-test, ANOVA, and Scheffe test using SPSS PC+16 version. Results: Individuals in the So Yin In group had significantly worse depression than those in the Tae Yin In group. Those in the Tae Yin In group tended to have a better quality of life than those in the So Yin In group, but no significant difference was observed. Furthermore, individuals in the Tae Yin In and So Yin In groups all had low quality of life scores comparing with median value. Significant differences in depression and quality of life according to age and subjective health status were observed in the Tae Yin In group. In the So Yin In group, significant differences in quality of life according to education and subjective health status were observed. Conclusion: A concrete nursing intervention based on the Sasangin constitution for elderly women should be explored to decrease depression and improve quality of life. Additionally, the general characteristics of elderly women should be considered to develop an appropriate nursing intervention.