Purpose: The purpose of this study was to evaluate the effects of a combination program of meridian massage and foot reflexology on stress and natural killer (NK) cell activity in adults. Methods: This study is a quasi-experimental research usingone-group-pretest-posttest design. The subjects of the study were 42 adults in T city. Stress level was assessed with systolic blood pressure, diastolic blood pressure, pulse rate, and serum cortisol level. The data were analyzed by SPSS/WIN 17.0 program with descriptive statistics and Wilcoxon signed-rank test. The period of this study was from January 4 to July 11 of 2008. The program was performed three days per week, two hours per session. Results: The degrees of perceived stress were significantly different while objective stress levels were partially different between pre-and post-program. The NK cell activity did not show a significant difference between before and after the program. Conclusion: This study suggests that combination of meridian massage and foot reflexology may be an optional nursing intervention to reduce subjective and objective stress in adults.