The performance of variable dampers for seismic protection of the benchmark highway bridge (phase I) under six real earthquake ground motions is presented. A simplified lumped mass finite-element model of the 91/5 highway bridge in Southern California is used for the investigation. A variable damper, developed from magnetorheological (MR) damper is used as a semi-active control device and its effectiveness with friction force schemes is investigated. A velocity-dependent damping model of variable damper is used. The effects of friction damping of the variable damper on the seismic response of the bridge are examined by taking different values of friction force, step-coefficient and transitional velocity of the damper. The seismic responses with variable dampers are compared with the corresponding uncontrolled case, and controlled by alternate sample control strategies. The results of investigation clearly indicate that the base shear, base moment and mid-span displacement are substantially reduced. In particular, the reduction in the bearing displacement is quite significant. The friction and the two-step friction force schemes of variable damper are found to be quite effective in reducing the peak response quantities of the bridge to a level similar to or better than that of the sample passive, semi-active and active controllers.